动物造模,血友病鼠模型 z-bio 2021-06-01 238

　　Hemophilia is a single-gene genetic disease. The main pathogenesis is that the coagulation factor coding gene mutation leads to the decrease of coagulation factor. The clinical manifestation is repeated bleeding, and the serious case is life-threatening. It may or may not heal. Is it possible to cure hemophilia? Is animal model an indispensable basic support condition in gene therapy research? Mouse models of hemophilia are easier to transport than other large animals, and research costs are cheaper. It has unique characteristics. It is a hot spot for hemophilia animal model research to stand out among many model animals. After more than 20 years of construction, hemophilia mouse models have gradually matured, which has greatly promoted the development of hemophilia gene therapy. Has become a patient with hemophilia.