动物模型,冠状动脉痉挛 z-bo 2020-08-06 575

　　(1) Reproduction method The female rhesus monkeys were surgically removed from the ovaries and used to contract vasoconstrictors to induce the contraction of the coronary arteries (hereinafter referred to as coronary arteries), and through coronary angiography to compare the differences with humans. This model focuses on the pathological changes of the local blood vessels in the monkey's coronary spasm. In the absence of pre-vascular pathological changes, endothelial damage and exfoliation, simply relying on ovariectomy can also induce postoperative monkey coronary arteries under the action of histamine, endothelin and angiotensin and other vasoactive substances. Coronary spasm obtained by endothelial peeling method.

　　(2) Model characteristics Ovariectomy is a commonly used animal model in the study of the relationship between sex hormones and coronary spasm in the field of coronary spasm mechanism. The establishment of rhesus monkey ovariectomy model has become an ideal method for research in this field. It is not only used in pathogenesis, but also widely used in drug screening, pathological changes and other aspects. This model simulates the reduced secretion of sex hormones in menopausal women who are susceptible to coronary artery disease, and provides a better experimental model for studying the pathogenesis of coronary artery disease in menopausal women.

　　(3) Comparative Medicine Coronary spasm, which does not rely on local diseased structures, and coronary spasm with local atherosclerotic plaques and injuries also play an important role in the occurrence of cardiac ischemic accidents. Researchers have found that after surgical removal of the ovaries of adult female rhesus monkeys, the reduction in the secretion of estrogen such as progesterone and estradiol in the body can lead to increased coronary vascular tension without endothelial damage and exfoliation. This model is similar to the clinical situation where menopausal women reduce the secretion of sex hormones and are susceptible to coronary artery disease.