【Animal Modeling】-What are the methods to construct animal models of nickel damage?

  Nickel is a metal element widely contacted by humans in daily life and production. It is an essential trace element for the human body. However, excessive accumulation can cause harm to the human body. At present, the damage mechanism of nickel poisoning to the human body has not been clarified, and further research and discussion are needed. The nickel damage model is the basis for studying the mechanism and treatment methods of nickel damage. Different nickel damage models have different preparation properties, and different experimental animal models must be selected for different experimental purposes. This article introduces some commonly used modeling methods.