动物造模,创伤后应激障碍 z-bio 2021-10-19 585

　　Post-traumatic stress disorder (PTSD) is a mental illness that can have a significant socio-economic impact after experiencing a major traumatic event with a high incidence. At present, the cause of PTSD is still unclear, which seriously hinders the development and application of clinical drugs. The establishment of animal models of diseases plays an important role in understanding the clinical manifestations, pathogenesis and treatment of PTSD. In recent years, researchers have proposed various animal models of PTSD to study behavior and molecular biology.

　　In this review, we will introduce how to establish a rodent PTSD model represented by rats and mice, summarize the research status of domestic and foreign researchers in recent years, select PTSD animal models, and further research on the disease. I mean it.