动物造模,降脂模型 z-bio 2021-06-03 1197

　　Hyperlipidemia is an important cause of lipid metabolism and cardiovascular diseases such as coronary heart disease, cerebral infarction, and arteriosclerosis. It is the "first killer" that threatens human health. At present, the development of high-efficiency and low-toxicity lipid-lowering Chinese herbal medicines is essential for improving hyperlipidemia and its secondary cardiovascular and cerebrovascular diseases. However, due to the complexity and compatibility of Chinese herbal medicine ingredients, it is difficult to conduct detailed studies on the effective ingredients and specific lipid-lowering mechanisms based on a single lipid-lowering model. Therefore, establishing an ideal hyperlipidemia model is one of the key factors for screening lipid-lowering Chinese herbal medicines and studying the etiology of hyperlipidemia in Chinese herbal medicines.

　　This article reviews the three most commonly used hypolipidemic models from the perspectives of cell models, mammalian models, and zebrafish models, as well as the general modeling methods and advantages of various models, and explains their shortcomings. The summary. Model selection to reproduce hyperlipidemia. To study the causes of hyperlipidemia, screen high-efficiency lipid-lowering Chinese herbal medicines, and provide reference and experimental basis