动物造模,血友病鼠关节病模型 z-bio 2023-01-17 452

　　Hemophilic arthropathy is a debilitating disease caused by recurrent spontaneous bleeding and hematoma in the joints. The main clinical symptoms are chronic pain, joint damage and poor quality of life. The biological mechanism is not fully understood. The current transformed animal models of hemophilia have important value in determining the pathophysiology of the disease and its complications. Therefore, it is necessary to establish a model of hemophilia arthropathy to further study the pathophysiological mechanism and possible interventional treatment of hemophilia arthropathy.

　　Hemophilia mice have become the preferred model for researchers due to their advantages such as easy transportation and easy construction. The constructed hemophilia arthropathy model provides the basis for future clinical research. To this end, we will discuss the construction and research of mouse arthropathy models of hemophilia.