猪动脉粥样硬化模型,动物造模 z-bio 2021-11-03 816

　　Miniature pigs are very similar to humans in terms of arterial anatomy and physiology, and are currently the most ideal model for studying atherosclerosis (AS) related diseases. So far, various methods that can simulate the AS model of mini pigs have been published. In addition to the traditional high-fat feed + balloon strain, new methods such as gene editing and local lipid injection for inducing spontaneous hyperlipidemia have also been announced. Including the coronary wall and inflammatory factors.

　　However, there is no mature and recognized model of coronary atherosclerosis in miniature pigs. Long modeling cycle, low success rate, and high cost are the bottlenecks that limit the research of piglet animal models. This article summarizes the breeds and methods of mini pigs suitable for modeling.