【Animal Modeling】-How to build an animal model of Parkinson's disease?

  Parkinson's disease (PD) is a neurodegenerative disease that seriously threatens human health. The typical pathological changes are the necrosis and loss of dopaminergic neurons in the substantia nigra, as well as many movement disorders. The cause of this disease is not yet clear, and the application of related animal models is of great significance to the study of the specific mechanism and treatment of the disease. Our current research on PD animal models.

  This article explores the characteristics of different PD animal models, discusses the different characteristics of different animal species in PD models, compares the clinical differences between animal models and PD patients, and considers PD animal models, aiming to provide reference for further research and development.