动物造模,食物过敏小鼠模型 z-bio 2021-06-04 652

　　Food allergies are rapidly becoming a global health problem. Food allergies are caused by harmless food-specific Th2 reactions, leading to IgE-mediated mast cell degranulation and related inflammation. The mouse model of food allergy can be used to study the pathology, physiology and new treatment strategies of human food allergy. Food allergy mouse models are divided into adjuvant-dependent models, adjuvant-free models, genetic engineering models and humanized models. However, no mouse model can reproduce the complete pathological characteristics of human food allergy. It is very important to use specific food allergy mouse models to solve specific food allergy research problems.

　　Combined with domestic and foreign research literature, summarized the research progress of various food allergy mouse models in the past 20 years and their advantages and disadvantages in the study of food allergy mechanisms, providing reference and scientific basis for studying the mechanism of food allergy. Develop new treatment strategies.