Chronic obstructive pulmonary disease is characterized by completely irreversible and persistent progressive airflow limitation, usually accompanied by acute exacerbations and severe complications. Establishing a standardized animal model that meets the clinical characteristics of COPD is very important for studying the development, development, morphological and functional changes of COPD, and new treatment methods. In recent years, domestic and foreign researchers have conducted many related studies, but there is no optimal model for constructing an animal model of COPD.
This article describes in detail the types of animals used to establish COPD models, the advantages and disadvantages of each model, and their clinical applications.