动物造模,高尿酸血症 z-bio 2021-10-11 682

　　Objective: To establish a stable and effective model of liver and kidney damage, gouty arthritis and other complications in rats with hyperuricemia.

　　Methods: 48 male Sprague-Dawley rats (hereinafter referred to as SD rats) were randomly divided into 6 groups (8 in each group), namely the blank control group (control group) and the oxazine potassium group (OA group)). . Potassium oxalate + hypoxanthine group (OA+H group), potassium oxalate + yeast extract group (OA+YE group), 10? Luctos+0.2? Tambutor group (10? U+0.2? B group), potassium 2? 12 Maternal special diet group (OAPO group) After 5 weeks of experiment with different concentrations of 5 drugs, the rats were tested for serum uric acid, creatinine, urea and other biochemical indicators, kidneys and joint synovial muscles were observed through pathological sections. .

　　Result: Compared with the blank control group, the OAPO group had higher serum uric acid levels, severe liver and kidney damage, and joint inflammation. The uric acid levels of OA, OA+H, OA+YE and 10?Ru+0.2?MB groups did not increase, but there were certain liver and kidney damage and joint inflammation.

　　Conclusion: The mixed diet of 2 potassium hydrochloride and 12 mother extracts is the most effective for establishing a model of hyperuricemia and complications. This is kidney damage caused by hyperuricemia and is also suitable for studying arthritis.