动物造模,人工耳蜗,基因疗法 z-bio 2021-06-07 359

　　Researchers at the University of New South Wales School of Medicine in Australia use a gene therapy called electrical gene delivery, which uses an electric field to restrict gene delivery to co co co cow electrodes. This study provides evidence that gene therapy can enrich the hearing of co-co-co cattle transplanters.

　　The use of gene therapy to improve the effectiveness of cochlear implants allows people with different degrees of hearing loss to distinguish between different instrumental tones, such as triangle jingle and soft piano sound. Maybe one day you will start to feel complicated sounds. The loss usually occurs after the loss of hair cells in co co cows. co co co Bovine hair cells are special cells in the inner ear. These help convert sound vibrations into electrical impulses in nerves. This is the process by which we hear the sound. Cochlear implants have been on the market since the 1970s and partially restore hearing by affecting the hair cells of co co co cows. However, current cochlear implants cannot restore hearing to normal levels, and the electrode design has remained basically unchanged for decades. In an experiment conducted on completely deaf guinea pigs, Jeremy Pinion and colleagues found that gene therapy stimulated the regeneration of cochlear implant neurons, which can convert different frequencies into sound perception. The researchers pointed out that performance can be improved.

　　Researchers used a type of gene therapy called electrical gene delivery, which uses an electric field to restrict gene delivery near cocoa cattle electrodes (it uses viruses to produce genes). It is related to the delivery method. It can cause the disseminated expression of certain genes transmitted by viruses). Pinyon et al. injected a DNA solution containing the brain-derived neurotrophic factor (BDNF) gene into a guinea pig cochlear implant, and used an electrode array to deliver several short electrical pulses to coco cows. Within a few hours, co-co-co-bovine cells received DNA and began to express neurotrophic factor, a protein that helps nerve cell development. The research team used the auditory brainstem response test (ABR) to test the hearing of guinea pigs. ABR is a common method used to detect the hearing of newborns. Electrodes are placed on the top of the guinea pig’s head to detect the electric current produced by the bovine nerve fibers in the brain in response to sound.

　　Researchers have found that the hearing of guinea pigs has been significantly improved, and the hearing of guinea pigs who have been completely deaf has returned to near normal levels. co co co provides ample evidence for the hearing of guinea pig transplanters. The researchers will then test the electric cattle electronic gene delivery technology in clinical trials. A related "focus" article describes these findings.