动物造模,小鼠模型实验,白血病干细胞 z-bio 2021-06-07 639

　　Although there are reports that chemotherapy is mainly used to treat leukemia, the leukemia stem cells in the bone marrow are difficult to remove, and the possibility of recurrence of leukemia is higher. So how to answer what happened to the bone marrow after chemotherapy started? How do leukemia stem cells escape the problem of chemotherapy? Another scientific problem is that treatment is very important for strategic research.

　　Researchers first injected human acute lymphoblastic leukemia cells into mice to establish a mouse model of leukemia, then received chemotherapy, and used advanced imaging technology for observation and research. done. Do it. Leukemia cells infiltrate the bone marrow, and it is found that the normal bone marrow microenvironment is basically destroyed. After chemotherapy, the leukemia stem cells secrete a variety of cytokines to supplement the bone marrow mesenchyme and traits. Stem cells escape chemotherapy and die. When the house was completely destroyed by the earthquake, the survivors set up temporary tents to survive the disaster.

　　Researchers discovered and identified this "temporary tent" in the bone marrow, and called this newly built "sanctuary" the microenvironment of the National Socialist Movement. The researchers called it NSM, and we called it the microenvironment. We found that by destroying the body's formation or protective function, the effect of chemotherapy can be significantly improved and the leukemia stem cells remaining in the bone marrow can be eliminated. At the same time, microenvironmental markers were detected in the samples of leukemia patients whose chemotherapy could not be relieved or partially relieved, while the microenvironmental markers were not detected in the samples of leukemia patients who were in complete remission.

　　The important significance of this research lies in the detection of markers to determine the prognosis of patients and interfere with their formation and function, thereby improving the effect of chemotherapy and even curing leukemia. That's it, experts believe it can be done. At the same time, this research may be applicable to other tumor treatments.