动物造模 z-bio 2021-09-29 727

　　Binge eating generally refers to the unrestricted swallowing of large amounts of food in a short period of time. People define binge eating as a bad lifestyle. Approximately 10 American adults have the bad habit of overeating, and most of them are women. Earlier data showed that women with irregular menstrual cycles are more likely to overeating. This shows that binge eating is closely related to estrogen. Overeating is suppressed when estrogen is prolonged, and overeating is easier when estrogen is low.

　　In order to study the relationship between binge eating and estrogen, researchers established a mouse model and found for the first time that estrogen can strongly inhibit binge eating in mice. This is very consistent with human data. Researchers speculate that women with irregular menstrual cycles are more likely to overeating, which may be related to the decline in estrogen function. Further studies have shown that estrogen receptors mediate the effects of estrogen on binge eating and receptor localization. use

　　In the mouse model, researchers found that the estrogen alpha-receptors expressed in serotonin neurons in the brain can inhibit the effects of binge eating through estrogen. It not only reveals the mechanism of estrogen to control overeating, but is also expected to open up a method of treating overeating with estrogen.

　　estrogen therapy is controversial because it easily causes its side effects and breast cancer. Researchers can only fully understand the role of estrogen, understand its advantages and disadvantages, and maximize its strengths and avoid its weaknesses. He said it can avoid its side effects and accelerate the development of estrogen therapy. According to the researchers, not long ago, researchers at the Indian University developed a complex compound called GLP-1-estrogen, which is released in areas where both GLP-1 and estrogen receptors exist. No. This compound does not deliver estrogen to breast tissue, thereby controlling weight.

　　After administering this compound to mice, it was found that the estrogen activity in the serotonin neuron area of the mouse brain was significantly increased, and the compound was able to deliver estrogen to this area. Further studies have shown that the estrogen GLP-1 can inhibit binge eating behavior. Previous studies have shown that GLP-1 levels in binge eating patients are reduced, but no one has found that GLP-1 can inhibit binge eating behavior in humans and animals. In the latest research, both GLP-1 and estrogen can inhibit overeating, and GLP-1-estrogen complex can bypass breast tissue and be affected by estrogen alpha expressed by serotonin neurons in the brain.

　　Next, the researchers hope to determine the mechanism by which estrogen regulates serotonin neurons and whether increasing serotonin levels can suppress overeating.