动物造模,线粒体DNA突变 z-bio 2022-01-12 677

　　A study published in "Science Reports" turned mice into humans, so the life span of humans may be determined to a certain extent before birth. This new study shows that mitochondrial DNA mutations in mother's egg cells can shorten the lifespan of mothers and children by about a third.

　　The pathology and clinical examination of the Children's Hospital of Philadelphia said: "The key point of this type of research is to prove that mitochondrial DNA (maternal inheritance) carries important genetic information." Professor of Medicine Douglas Wallace said. Wallace did not participate in the new study, but independently showed that the mitochondrial gene mutation inherited from his mother can affect aging, longevity and cancer.

　　This new article is based on an article published in the journal Nature last year, which pointed out that in other wild-type mice, mutations in maternal mitochondrial DNA are sufficient to cause premature aging. The Gerald Professor of Discovery Pathology and Genetics at Yale University's Shadell University described it as a "real breakthrough."

　　But because of the enthusiasm for publishing this new discovery. "I don't know if this will affect their lifespan," said Jamie Ross of the Karolinska Institute, two papers, scientific reports and the first role of nature. It takes about a year to wait for the animal to die.

　　The average lifespan of mice with genetic mutations in mitochondrial DNA is 100 weeks, while the average lifespan of the control group is 141 weeks. Douglas Turnbull, professor of neurology at Newcastle University (who was not involved in the study), said the results were "interesting but not surprising" because prematurely aging animals die young. I will.

　　But I don’t know why mitochondrial DNA mutations shorten lifespan. Mitochondrial dysfunction can affect cell metabolism and cause a variety of problems, including the accumulation of harmful reactive oxygen species, decreased stem cell viability, and decreased DNA repair, all of which can lead to the accumulation of nuclear genome damage. "Aging is a complex process involving many different aspects: all of this is a gradual combination of constantly defeating biology in a short period of time."