动物造模,人体细胞,人类肠道 z-bio 2021-06-07 385

　　According to foreign media reports, American scientists have successfully cultivated fully functional human intestinal tissues in mice. This breakthrough in research may lead to thousands of intestinal diseases in the future. The pediatric surgeon at the Children's Hospital of Los Angeles was suffering. The study successfully transplanted human cells into mice, and finally "transplanted" into mice. The function of this small intestine is similar to that of a real small intestine.

　　The doctors at Los Angeles Children’s Hospital hope that these findings will help treat a range of gastrointestinal diseases and improve the survival rate of diseases such as short bowel syndrome. Short bowel syndrome is a terrible disease. One-third of young patients die within five years. The study was led by Dr. Tracy Glickschet of Los Angeles Children's Hospital.

　　A previous study conducted by the Los Angeles Children's Hospital found that transplanting donated human tissue into mice can cultivate the so-called "tissue engineered small intestine." In the first study, the small intestine they cultivated had limited function. The results of the study were published in the 2011 biomedical journal "Tissue Engineering A". As part of a new study, the researchers created a tissue-engineered small intestine with the same important functions as the human small intestine, such as the mucosal lining found in the fully developed small intestine. Test results show that the tissue-manipulated small intestine can break down sugar into glucose and secrete intestinal hormones at the same time.

　　The tissue-modified small intestine cultured in mice is highly similar to the tissue-modified small intestine cultured in human cells. Both have important "components" such as stem cells and progenitor cells and were selected. Stem cells and progenitor cells regenerate the intestine and act as a substitute for living tissue. During the research process, scientists extracted cells from human small intestine tissue and immersed them in a digestive enzyme solution. The solution was packed into a so-called polymer scaffold used to support the development of cells and tissues and transplanted into mice. Four weeks later, they bred a tissue-engineered small intestine and tested it.

　　Scientists have discovered in experiments that the tissue-manipulated small intestine can break down sugar into glucose, and the inner cells are also very similar to other specific cells. These cells help to form a fully functional organ, allowing the body to have a healthy intestine. Dr. Glickschetter said: "We have demonstrated that compared with other stem cell or progenitor cell models currently used for intestinal regeneration and disease research, we can cultivate small intestines with more complex tissue functions. It is proved that the small intestine created by this tissue engineering is fully functional. It is an important milestone and an important step to help patients with bowel disease. This means that we have taken a step forward."

　　The successful culture of functional tissue engineered small intestine demonstrates that surgeons can further realize the dream of "treating patients with regenerative medicine technology." Tissue engineered small intestine can be used to treat short bowel syndrome. This disease can cause intestinal dysfunction, especially Premature babies and newborns with congenital intestinal problems. In the future, intestinal transplantation through the modified small intestine is expected to solve the problem of shortage of donated organs. If the intestines are not long enough, the baby will have to rely on parenteral nutrition, which will lead to Liver damage. Statistics show that about 24 of every 100,000 live births suffer from intestinal failure, and nearly one-third of the patients die within five years.