【Animal Modeling】-How to use zebrafish to study organ regeneration?

  The zebrafish is about 4 cm long with dark blue and silver stripes. Gene 87? Human-like. The heart can regenerate about 2000 human diseases. The embryo develops in vitro and is completely transparent.

  "The gene of zebrafish is as high as 87 of humans. Humans grow a second heart. The heart of zebrafish can regenerate, although it is not allowed." Yesterday, we learned from the national zebrafish resources that this is a major national scientific research project. , "Research on Genetic Control of Heart and Liver Development and Regeneration". The center recently completed a mid-term summary, hoping to unlock the mystery of organ regeneration through zebrafish research. In a laboratory of approximately 250 square meters, 50,000 zebrafish move back and forth between culture vessels. Researchers sometimes feed them and record relevant data.

  The National Zebrafish Resource Center was established with the support of the Ministry of Science and Technology and the Chinese Academy of Sciences, and settled in Wuhan in October last year. The director of the center, Sun Yonghua, introduced that zebrafish are tropical fish and their place of origin is not in China. Because it is so close to human genes, zebrafish can suffer from approximately 2,000 human diseases, including colds, leukemia, atherosclerosis, and cancer. Therefore, if you want to develop a treatment for one of the above diseases, you can first test its effect on zebrafish.

  There are currently more than 1,500 laboratories in the world studying zebrafish, and there are nearly 100 zebrafish laboratories in my country.

  Over the past year, it is understood that the center has collected and created a collection of more than 100 zebrafish genetic variations to serve national zebrafish research scholars. The center is expected to become the world's second largest zebrafish resource center within two years.

  "Zebrafish are very popular with scientists because they are economical laboratory animals." According to reports, zebrafish embryos are in vitro, unlike well-known laboratory animals, mice, because they develop in the body and are completely transparent, so scientists can easily observe Embryo development process. A pair of zebrafish can produce 300 "fish babies" at a time, which can meet many operational requirements of the experiment. In addition, one day of zebrafish embryo development is equivalent to 21 days of human embryo development in the mother's body, saving experimental time.