动物造模,斑马鱼心脏再生 z-bio 2021-06-07 392

　　The Institute of Molecular Medicine of Peking University successfully established the first fluorescent reporter system for hydrogen peroxide (H2O2) signals in living hearts, revealing that H2O2-Dusp6-pERK signals regulate zebrafish heart regeneration.

　　The research team found that damage-induced Duox and Nox2 act as active oxygen signals, which can reduce the inhibition of the epicardium by reaching a maximum concentration of 30μM during the production of H2O2 and degrading the redox-sensitive phosphatase Dusp6. It is found that the MAPK signal pathway is distributed in the myocardium and enhances pERK, promotes myocardial proliferation and regeneration, and inhibits myocardial fibrosis.

　　This study further revealed that BCI, a small molecule inhibitor of Dusp6, can promote heart regeneration. This study uses the zebrafish heart regeneration system to reveal the molecular mechanism of heart regeneration, indicating that small molecule drugs that promote heart regeneration can be found. These new results are expected to provide a theoretical basis for improving human heart regeneration.

　　The authors of this book are Professor Xiong Jingwei and Professor Cheng Heping. Postdoctoral fellows of the Institute of Molecular Medicine of the Han Peidong Institute of Molecular Medicine, Zhou Xiaohai and Ph.D. students Zhou Xiaohai and Chang Nannan are the co-first authors of this book. Other participants included Professor Li Chuanyun from the Institute of Molecular Medicine, associate researcher Zhu Xiaojun, and Professor Zhang Chuanmao from the School of Life Sciences. This work has been strongly supported by many scientific research projects such as the 985 Special Project of Peking University, the 973 Major Basic Research Program of the Ministry of Science and Technology, and the Major Development and Regeneration Research Program of the Ministry of Science and Technology. China National Foundation.