肿瘤干细胞,动物造模 z-bio 2021-06-08 491

　　Recently, the international biology journal celldeathu0026differentiation published the latest research by Canadian and Chinese scientists. Researchers have shown through in vivo and in vitro experiments that activation of Toll-like receptor 3 (TLR3) can promote the transformation of breast cancer cells into cancer stem cells (CSCs) and produce stem cell properties. β-catenin and F-κB signaling pathways may occur. The results of this study provide a new strategy for suppressing the production of CSCs in cancer treatment.

　　In 2012 statistics, researchers pointed out that breast cancer is the second leading cause of death for women. Traditional treatments such as radiotherapy and chemotherapy can eradicate tumor masses. Although they cannot completely kill a small number of malignant tumor cells, these malignant tumor cells can still be killed. Survive, self-renew, and develop into malignant tumors. These cells are cancer stem cells. is called. cell. Studies have shown that cancer stem cells are resistant to conventional treatments and can be transformed from non-cancer stem cells under certain conditions. Although TLR3 is more expressed in breast cancer patients with poor prognosis, the relationship between TLR3 and the transformation of breast cancer cells into cancer stem cells is still unclear.

　　Researchers have found that the activation of TLR3 can promote breast cancer cells to produce functions similar to cancer stem cells, but TLR5, 7, and 8 cannot play the same role in cells in vitro. First discovered through cultivation. Further exploration found that activation of only the NF-κB signaling pathway does not allow breast cancer cells to transform into cancer stem cells, resulting in the simultaneous occurrence of β-catenin and NF-κB signals, which can promote breast development through TLR3 after activation. Transformation of cancer cells Transformation of cancer stem cells. The researchers also found that treating breast cancer cells with cardamom can block the β-catenin and F-κB signaling pathways and inhibit the TLR3-mediated CSC conversion process.

　　"To sum up, in this study, TLR3 can simultaneously activate β-catenin and NF-κB signaling pathways to promote the transformation of breast cancer cells into cancer stem cells, and cardamom blocks this effect of TLR3. The growth of tumor cells The transformation of cancer stem cells. The results of this study provide a new strategy for inhibiting the production of CSCs and improving the cure rate of cancer.