脊髓性肌肉萎缩症,动物造模 z-bio 2023-01-18 665

　　A few days ago, the Institute of Neuroscience of Soochow University and Professor Hua Yimin of Cold Spring Harbor Laboratory in the United States developed a number of mouse disease models, which effectively increased the expression of motor neuron survivors in peripheral tissues. I found that it worked. Treatment of spinal muscular atrophy. Related research results have been published in the internationally renowned biomedical journal Genes and Development. Hua Yimin is the first author and co-author.

　　Spinal muscular atrophy is a recessive autosomal inherited disease and the main cause of infant death. In a recent study, Hua Yimin and his American collaborators designed a sense oligonucleotide called "bait" and injected it into the ventricle of mice to interfere with the drug's central nervous system. Function in the nervous system and protect motor nerves. Limited to peripheral tissues. Surprisingly, this treatment can extend the lifespan of mice by more than 20 times. This discovery breaks through the status quo in this field. It is believed that the treatment of spinal muscular atrophy needs to increase the expression of survivin motor neurons in the spinal cord.