动物造模 z-bio 2021-06-08 664

　　Researchers from the Institute of Zoology, Chinese Academy of Sciences have recently discovered an important inflammatory factor for lung cancer caused by smoking through animal modeling technology.

　　Data shows that about 1.6 million people die from lung cancer every year, 90% of which is smoking. Tobacco contains 5,000 compounds, of which 73 are found in laboratory animals and humans. On the other hand, it is carcinogenic. Smoking can cause DNA damage and gene mutations, but the mechanism of lung cancer caused by smoking is still unclear, which is a prerequisite for formulating lung cancer prevention and treatment strategies.

　　Researchers treated normal human lung epithelial cells with tobacco carcinogen nicotine-derived nitrosamines for 60 days, and then tested the changes of 84 cytokines and chemokines in normal lung epithelial cells, and found that the expression level of nicotine-derived nitrosamines can be chemotactic The factor CCL20 increased significantly. They tested the expression of CCL20 in cancer tissues of lung cancer patients and found that 48 of 92 lung cancer patients who smoked had increased CCL20 expression. Among 78 non-smokers, 29 showed high expression of CCL20. This indicates that the expression level of CCL20 is related to smoking. according to

　　Research, the higher the expression of CCL20, the shorter the survival time of patients. In cells and experimental animals, nicotine-derived nitrosamines promote the growth and metastasis of lung cancer cells by inducing the expression of CCL20. . Anti-inflammatory drugs block the expression of CCL20 and block the growth of lung cancer cells. These results indicate that CCL20 is not only an important inflammatory factor for lung cancer induced by smoking, but also a new target for lung cancer treatment.