动物造模 z-bio 2021-06-08 591

　　Recently, the reporter learned from the University of Science and Technology of China that Professor Gao Linliang's group from the School of Chemistry and Professor Zhang Huamin's group from the School of Life Sciences discovered "intelligence." A new method to overcome tumor multidrug resistance The excellent anti-multidrug resistance effect has been tested in mice.

　　A phenomenon in which tumor cells are exposed to specific chemotherapeutic drugs for a long time, which leads not only to the development of drug resistance to the chemotherapeutic drugs, but also cross-resistance to other chemotherapeutic drugs of different structures and functions. It is one of the important reasons for the failure of cancer chemotherapy and the biggest challenge in the clinical treatment of cancer. The traditional method to solve this problem is to block the pumping effect of multidrug resistance or use nano-carriers to load large amounts of drugs, which often produce unwanted toxic substances and bring them into the body. Therefore, it is very important to develop safer anti-multidrug resistance drugs.

　　Liang Gaolin’s research team designed a method to “modify” the drug itself. The modified drug “smartly” self-assembles in cancer cells to produce nano-drugs, targeted enrichment, and the drug has the ability to delay release, which is for drug research and development. Provides new ideas. The development of anti-multidrug resistance. The "smart" small molecule drug (2-cyanobenzothiazole-paclitaxel) they designed after entering cancer cells, through the action of highly expressed intracellular enzymes, self-organizes nanoparticles containing paclitaxel, which can be made and concentrated. cell. Nanomedicine slowly releases free paclitaxel in cancer cells through the action of esterase to kill cancer cells.

　　They cooperated with Chang Huafen's research team to establish a multidrug resistance model of cancer cells and experiment with live tumor mice. Compared with the existing drug paclitaxel, 2-cyanobenzothiazole-paclitaxel proved to be resistant Sex, once in the cancer cell and once in the mouse body, it is non-toxic to the mouse.

　　Liang Gaolin said that this new multi-drug resistance strategy provides new ideas for safer drug design and cancer treatment, and has great potential for the clinical treatment of cancer.