动物造模,阿尔茨海默氏症 z-bio 2021-06-09 310

　　A cancer drug treatment method activated by the immune system can improve cognition and memory, and reduce lesions in mice with Alzheimer's disease. This is a study published online in "Nature-Medicine" the conclusion. The study found that immune checkpoint blockade can be used as a potential treatment for Alzheimer's disease, and this method may also have a therapeutic effect on other neurodegenerative diseases.

　　Immune checkpoint is a pathway in immune cells that can activate and suppress immune response. Programmed apoptosis-1 (PD-1) blockade is a cancer drug treatment, recently approved by the US Food and Drug Administration, which can block the PD-1 immune checkpoint pathway, thereby activating immune cells and attacking cancer cells .

　　In this study, Michal Schwartz et al. treated some genetically modified mice that showed features of Alzheimer's disease. These mice produced toxic beta amyloid (Aβ) plaque deposits in their brains, which gradually produced memory Hinder. The researchers found that compared with mice treated with placebo or untreated, those mice treated with PD-1 blockade twice three days had improved memory function in the month after treatment. , Brain lesions and inflammation have been reduced. In addition, the researchers also observed that the learning, memory and pathological conditions of the mice that had been treated for two consecutive months had more significant improvements. They believe that PD-1 blockade promotes the replenishment of protective immune cells in the brain and subsequently promotes the removal of toxic Aβ plaques.