动物实验,艾滋病病毒 z-bio 2021-06-09 718

　　German researchers reported on the 22nd that they are developing a new method that is expected to help patients remove HIV from the body. Animal experiments have been successful.

　　HIV, like other retroviruses, its genetic material will be integrated into the human host genome for replication during reproduction. Although current antiretroviral therapy can effectively inhibit the reproduction of HIV, it cannot eradicate this type of integrated virus. Therefore, the virus can stay dormant during the treatment, and once the treatment is stopped, it will start to replicate again.

　　The Dresden University of Technology in Germany issued a press release on the same day, stating that the university has cooperated with researchers from the Heinrich Petter Institute in Hamburg to develop a new product called Brec1 using the "Molecular Directed Evolution" method, an important tool for protein modification.的recombinase. Test-tube cell specimens and laboratory mouse experiments show that this recombinase can accurately locate and identify more than 90% of clinically common HIV strains, and can safely and accurately "cut out" the integrated provirus from the genome of infected cells.

　　The so-called provirus refers to the potential viral genome that exists in the host chromosome. Experiments also showed that this method did not disrupt the function of host cells and normal genes. After the original virus is eliminated, the immune system, which has failed due to the interference of HIV genetic material, is expected to return to normal.

　　Researchers said that this method is expected to bring fundamental changes to the treatment of AIDS, making it possible to cure it completely. Based on the current animal experiments, researchers have been approved to conduct preliminary clinical trials on AIDS patients in the next step.