艾滋病,动物实验 z-bio 2021-06-09 298

　　A US research team reported that a single injection has developed a treatment that can protect monkeys from the monkey version of HIV (SHIV) for nearly six months. This research is very important to prevent the spread of AIDS to high-risk groups.

　　Passive immunization against hepatitis A can protect people for months before they get an effective vaccine. Previous studies have also shown that obtaining HIV-1 virus antibodies within 1-2 days before animals are exposed to high doses of virus also shows its ability to block viral infections. However, the long-term efficacy of this passive immunotherapy has not yet been experimentally confirmed.

　　In a new study, Malcolm A. Martin of the National Institute of Allergy and Infectious Diseases and his colleagues can solve this problem and whether passive immunotherapy similar to hepatitis A can continue to fight HIV infection.

　　Researchers published a paper on the ature magazine website to simulate how humans were infected with HIV in 9 rhesus monkeys in the control group to detect the infection. The average time to do this is 3 weeks. Then they injected 3 different antibodies into 3 groups, each consisting of 6 animals, and exposed them to the virus for 1 week. The virus infection time of all antibody groups is delayed, and the longest protection period lasts for 23 weeks, which is directly related to the strength of the antibody and the half-life. They also found that introducing amino acid mutations can extend the half-life of the weakest antibody.

　　Researchers claim that such antibodies improve the overall ability to block the spread of drug-resistant HIV-1 virus strains and provide a proof of concept for the prevention and treatment of HIV-1 virus. However, further research is needed to see if this therapy is effective in humans and whether it can replace the HIV-1 virus.