阿尔茨海默病,Y染色体丢失 z-bio 2023-01-16 637

　　Because male blood cells do not have a Y chromosome, they are more likely to be diagnosed with Alzheimer's disease. In addition, it is a factor that increases the risk of death, including many types of cancer.

　　The loss of Y chromosomes in blood cells has evolved into a biological explanation that reveals why men’s life expectancy is shorter than that of women. We published a research report in the Journal of Human Genetics showing that missing samples of the Y chromosome in the blood of men cause Alzheimer's disease. The same is true for people who carry the gene for this disease. The results of this study will be announced at the annual meeting of the European Society of Human Genetics. Researcher of Immunology, Genetics and Pathology, Uppsala University, Sweden

　　Lars Forsberg said: "Recent genetic research is mainly focused on genetic variation inherited through offspring. Mutations acquired in daily life." First author Jan Dumanski said the leader of the study, "Using new tools to analyze as we age The accumulated genetic variants, the clinical symptoms of sporadic diseases such as cancer and Alzheimer's disease will help explain."

　　A postzygote mutation found in living male cells, to be precise, is the loss of certain Y chromosomes in blood cells. The incidence of Y chromosome loss in men is 17, and older smoking men are more likely to find Y chromosome loss. This study broadens the view that Y chromosome deletion is a high risk factor for cancer (10.1038/ng.2966). Alzheimer's disease. For a long time, people have not known why the loss of the Y chromosome is related to the increase of risk factors for the disease. However, the author speculates that this may be related to the poor performance of the immune system.

　　We surveyed more than 3,000 men to determine whether there is a predictable association between the loss of the Y chromosome in blood cells and Alzheimer’s disease. The participants in the experiment came from three long-term studies that can provide routine blood samples: voluntary participants in European Alzheimer's disease, adult men in the Urapura longitudinal study, and elderly people in the Urapura prospective study. In the entire data, blood cells have the highest ratio of blood cells without Y chromosomes, and are more likely to be diagnosed with Alzheimer's disease all the time. "The loss of Y chromosome is not 100? Predicted. It could be cancer or Alzheimer's disease,"

　　Forsberg said. He added: In this experiment, a mutated, disease-free person can live to 90 years old. But in the future, blood cells that have lost the Y chromosome can become a new marker of disease risk factors. Perhaps evaluation can make the early detection and treatment of disease unique.

　　Forsberg, Dumanski and his colleagues will study the effects of Y chromosome loss in a larger group, and will study in more detail how they harm certain types of cancers and diseases. They also plan to observe cell changes caused by the loss of the Y chromosome. The loss of the Y chromosome and how other types of blood cells are affected.