糖尿病,动物实验 z-bio 2021-12-31 541

　　"One injection should last at least four months." A research team in the United States has developed a new drug to control blood sugar and has achieved success in animal studies. According to the researchers, the research involves hormones that are naturally present in the human brain and is expected to help treat diabetes in the future. Related papers are published online on the website of "Natural Medicine" magazine.

　　Type 2 diabetes is currently one of the most common diseases, and its incidence is increasing year by year around the world. It is characterized by a pathological rise in blood sugar levels, if not controlled, it may cause serious complications and even life-threatening.

　　Previous studies have shown that injection of the hormone fibroblast growth factor 1 (FGF1), which is involved in a variety of biological processes, into the peripheral blood system of mice has a strong anti-diabetic effect. ...However, achieving this goal requires large doses of drugs and large doses of injections.

　　Mike Schwartz of the University of Washington and his team changed their minds and tried to inject hormones directly into the brains of type 2 diabetic mice and rats. A single injection of FGF1 will cause the blood sugar of these animals to rise. We found that this value can remain normal for at least 4 months.

　　Researchers said that the therapy is effective for both diet-induced obesity and gene-induced obesity in mice. In addition, the therapy is also effective in genetically induced obese rats. It has been confirmed. This long-term anti-diabetic effect is not affected by food intake and body weight, indicating that this improvement in blood glucose levels has nothing to do with weight loss. This research fully demonstrates that the brain can have a powerful influence on blood glucose signals throughout the body.

　　This therapy is currently only effective for rodents with mild diabetes, but because it involves hormones naturally produced in the human brain, Schwartz said that this discovery may become a clinical drug for the treatment of diabetes. However, the specific treatment mechanism is still unknown, so further research is needed to answer this question and determine whether FGF1 has side effects.