动物造模,H5N1禽流感 z-bio 2021-09-23 558

　　A research team from the Chinese Center for Disease Control and Prevention, Yu Hongzai, systematically collected data on human cases of H5N1 avian influenza in 18 years from 1997 to 2015, showing the epidemiological characteristics of human H5N1 avian influenza for the first time. , And risk factors related to the epidemiological characteristics of the epidemic in Egypt since 2014 and after November. Related results were published online in the journal "The Lancet-Infectious Diseases" a few days ago.

　　Since the world’s first human case of highly pathogenic H5N1 avian influenza was found in the Hong Kong Special Administrative Region in 1997, the H5N1 avian influenza virus has spread globally in the past ten years, resulting in high human mortality. Studies have speculated that the virus may evolve into a virus that causes a human influenza pandemic through genetic recombination or mutation, and therefore has attracted worldwide attention.

　　Hongjie Yu’s research team systematically compiled data on 907 human cases of H5N1 avian influenza from May 1997 to April 2015 and their possible exposure factors. feature.

　　Outbreaks of human avian influenza H5N1 were found to mainly occur in East Asia, Southeast Asia and North Africa. From 2003 to 2008, it gradually spread from East Asia to Southeast Asia, West Asia and Africa. The global human avian influenza H5N1 fatality rate is 53.5, but it varies from region to region. Globally, 67.2 cases occurred from December to March of the following year, with the most reported cases in 2015. The median age of patients is 19 years old, which is less than 80-35 years old cases, but the median age of death in Egypt is higher than that in East Asia and Southeast Asia.

　　The study also showed that humans infected with the H5N1 avian influenza virus clade 1, 2.1, and 2.3 have a higher case fatality rate than clade 0 and 2.2. In Egypt, the human avian influenza H5N1 epidemic showed an upward trend from November 2014 to April 2015. , But the fatality rate, poultry contact history, time from onset to hospitalization, etc. are significantly different from the previous period, and there is no significant difference.

　　This research provides a scientific basis for the next step in the development of vaccines and antiviral drugs, as well as the research and prevention and control of the driving factors of the epidemic.