动物实验,乳腺癌转移 z-bio 2021-06-10 558

　　The reporter learned from Tongji University that the research team of Mr. Gao Jia from the Institute of Life Science and Technology of Tongji University and the Tumor Metastasis Institute of Tongji University Dongyang Hospital has discovered the gene TM4SF1 that promotes breast cancer multi-organ metastasis and the results have been announced. It is published in the cell. Experts believe that blocking and preventing the expression of this gene is the main target for the treatment of breast tumor metastasis and recurrence.

　　Tumor metastasis and recurrence are the most direct causes of death in most cancer patients. Although tumor metastasis and recurrence have important clinical significance, in the process of tumor metastasis to multiple target organs, especially in related studies, the existence of core genes is very weak.

　　Gao Hua's research group uses mouse models as in vivo screening tools to screen high-throughput, genome-wide, and functionally related genes, and find molecules directly related to breast cancer, lung cancer and other metastases and recurrences. The platform has been established. Tumors and their cellular and molecular mechanisms. In 2014, the research team discovered that TM4SF1 plays an important role in the self-renewal of normal stem cells and cancer stem cells.

　　Based on this, the researchers used immunohistochemical methods to analyze the tissue microarrays of 147 breast cancer patients, and continuously obtained complete clinical information, and improved the TM4SF1 gene of breast cancer patients. It has been found that it is controlled and the patient's survival The time is significantly shortened; on the contrary, the survival time is significantly prolonged. By using computer biometric information to analyze 3455 cases of breast cancer primary and metastatic tumor tissues, similar results were obtained. In addition, the intensity of TM4SF1 gene expression can be used to predict the time of tumor metastasis in breast cancer patients.