动物造模,阿尔茨海默氏症 z-bio 2021-06-10 524

　　Scientists first discovered a mysterious atrophic cell in the human brain and confirmed that it seems to be related to Alzheimer's disease.

　　"I don't know if they are the cause or the result," said Marie Ave Trenbray of Laval University, Quebec, Canada. She recently announced the discovery at the Translational Neuroimmunology Conference in Montana.

　　These cells look like atrophied forms of microglia. Microglia keep the brain clean and prevent infection. This is usually achieved by trimming unwanted brain connections or destroying abnormally infected brain cells.

　　However, the cells found by Trenbray appear darker and more destructive under the electron microscope. "It takes a long time to identify them." These contracted cells, Trenbray said, did not show the same color of the chemical substance that would normally make microglia visible under a microscope.

　　Compared with normal microglia, these darker cells have tighter connections with neurons. It seems to surround the synapse. "They are very active near the synapses." Where these microglia appear, the synapses usually shrink, and in the process

　　Tremblay are these dark colors. We first found microglia in mice and confirmed that their number increases with the age of mice. At the same time, these cells have been found in many mouse models of stress, neurodegenerative diseases, Huntington's disease, Alzheimer's disease and so on. It seems to be related to this. "Alzheimer's mice have 10 times higher black microglia than control mice," Tremblay said.

　　Now she has detected these cells in the human body for the first time. Trenbray analyzed the brains of Alzheimer's patients who died at the age of 45 and found that the black microglia in their bodies were about twice as large as the brains of healthy people of the same age.