动物造模,帕金森病 z-bio 2021-06-11 701

　　New research from the University of Queensland in Australia may lead to the development of new treatments for Parkinson's disease, which can be used to treat nearly 50 other diseases in the future.

　　In Parkinson's disease, which affects approximately 8 million people worldwide, important neurons in the brain are dysfunctional or die.

　　In this study, researchers from the Institute of Molecular Biology at the University of Queensland studied genetic mutations that interfere with the transport of substances in neurons and accumulate waste products that cause Parkinson’s disease. The related research results were published in the Journal of Biological Chemistry on August 26, 2016. The title of the paper is "Parkinson Disase-linkedVps35R524WMutationImpairstheEndsomeAssociationofRetromerandInducesα-SynucleinAggregation". Associate Professor, Institute of Molecular Biology, University of Queensland,

　　The corresponding author of the paper, Ohan Teasdale, discovered in a previous study a reverse transcriptase (a protein complex involved in the transportation of biological substances in cells). This dysfunction is related to Parkinson's disease, but the biological reasons behind it are currently unclear.

　　Teasdale said, "We have confirmed that in some Parkinson's disease patients (R524W), the retrograde complex protein Vps35 has a mutation, which blocks the transport network within the neuron."

　　"Therefore, the neurons involved in the protein complexes of the material cycle cannot reach the normal position of action. Without their support, these neurons in the brain will clear waste by themselves."

　　"This cell death can cause Parkinson's disease symptoms, such as tremor and muscle stiffness."

　　Teasdale said this research is still too early. Although one stage is mentioned, this discovery may improve the symptoms of Parkinson's disease. treatment.

　　He said, “As part of this research, we may expand the transport network inside these neurons to restore the transport process and allow these neurons to clean up their waste.”

　　"We believe that we will expand our ability to recycle. These neurons may be able to prevent or significantly delay the onset of Parkinson's disease."

　　Teasdale is caused by the accumulation of waste in the cell. He said that the same treatment principles can be applied to nearly 50 other diseases. These diseases are called

　　Lysosomal disease, which affects different parts of the body, including bones, brain, skin, heart, and central nervous system cells, is especially common in young children.