动物造模,长时程抑郁小鼠模型 z-bio 2021-09-28 349

　　Objective: To establish a new type of long-term depression model (long-term depression model, LTD) mouse, and compare the advantages and disadvantages of this mouse with the general depression mouse model.

　　Method: Use the separation of premature mothers and infants after weaning and continuous chronic stress to construct LTD mice, and compare them with chronic unpredictable wild stress (CUMS) and early life stress model (ELS) mice. Changes in hippocampal neurons in eGFP transgenic LTD and control mice compared to changes in depression-like behavior.

　　Result: Compared with CUMS and ELS mice, LTD mice can show long-term stable behavioral inhibition. Tissue sections showed degeneration of hippocampal CA1 and CA3 areas in LTD mice.

　　Conclusion: We have successfully built an LTD mouse. This model mouse can cause long-term depression-like behaviors and exhibit long-term psychological stress. This is a model mouse suitable for simulating long-term depression.