Depression is a common mood disorder that can be caused by many reasons. The main clinical feature is significant and persistent depression, which is irrelevant to the context. In severe cases, suicidal ideation and behavior may occur. The study of animal models of depression is the basis for studying the pathogenesis of depression and developing clinical drugs. Among them, the stress model has become the most commonly used animal model of depression through appropriate simulation of the onset of depression and simple modeling methods, and is widely used in basic research on depression.
This article reviews the main methods for evaluating stress-induced depression animal models, and provides references for establishing animal models of depression.