动物造模,核纤层蛋白病 z-bio 2021-06-16 652

　　The LMNA gene encodes type A lamin (lamin), and its mutation leads to a series of complex and diverse genetic diseases. At present, more than 900 LMNA gene mutations have been discovered, leading to different phenotypes of laminopathy.

　　Examples: Mandibular dysplasia (MAD), Emery-Dreifth muscular dystrophy (EDMD), premature aging (Hutchinson-Gilford premature birth syndrome, HGPS), etc. In order to better understand the molecular mechanism of lamina disease and the screening of therapeutic drugs, the researchers constructed a series of mouse strains with LMNA gene mutations. These mouse models are designed to understand the function of laminopathy and its impact on individuals. Growth and development provide valuable research materials.

　　This article reviews mouse models of laminar lesions and explains their importance in laminar lesions and physiological aging.