动物造模,子痫前期大鼠小鼠模型 z-bio 2021-10-13 1191

　　Preeclampsia is a unique pregnancy disease, and it is one of the main causes of morbidity and death in pregnant women and perinatal infants. The cause is unknown, and abortion is now considered an effective treatment. With the progress of society, the demand for safety during pregnancy has gradually increased. Establishing an ideal animal model of PE can undoubtedly provide a good way to study its etiology and pathogenesis, so as to better prevent or delay disease progression and reduce maternal and fetal mortality. , And improve the safety of pregnancy. Foundation and platform.

　　Large mice and mice are widely used in clinical animal research of major diseases due to their economic, accessibility, high survival rate, short pregnancy cycle and other advantages. With reference to domestic and foreign literature, PE models in mice and rats are classified as models of reduced uterine blood flow, excessive activation of inflammatory immunity, vascular endothelial cell damage, hypercoagulability, and genetic recombination.