动物造模,大鼠颅骨缺损动物模型 z-bio 2021-06-17 595

　　Objective: To explore an ideal method to establish a rat skull defect model, and to improve the success rate of animal models of bone defect.

　　Method: Select 40 adult male SD rats and randomly divide them into a control group and an experimental group. In the control group, the conventional skull defect model surgery method was used, and only the hollow ring drill bit perpendicular to the surface of the skull was used. The experimental group drilling a full-thickness skull defect adopted an improved surgical method, using hollow drills and solid drills to reorient the drill force at all stages of the skull drilling process. The alumina bioceramic materials embedded in the two models were compared with the two models' surgical drilling time and the presence of complications such as periosteum, dura mater, brain tissue injury, and bleeding during the operation. Observe whether they are displaced after one week. Compare the operation, loosening and osseointegration, and the success rate of modeling between the two groups.

　　Results: Compared with the control group, the surgical excavation time of the experimental group was significantly shortened (Pu003c0.01), and intraoperative complications such as periosteum, dura mater, brain tissue damage, and hemorrhage were significantly reduced (Pu003c0.01). Alumina bioceramic material There was no displacement or looseness after the operation (Pu003c0.05), the material was well integrated with the skull, and the success rate of model building was significantly improved (Pu003c0.05). 05).

　　Conclusion: An improved method for establishing a rat skull defect model has the advantages of shorter surgical drilling time and fewer complications. This greatly improves the success rate of model establishment and can effectively evaluate the bone repair performance of orthopedic implant materials in vivo.