动物造模,抑郁样大鼠模型 z-bio 2021-10-21 561

　　Depression is a mental illness with typical symptoms such as decreased mood, delayed thinking, and reduced speech activity. In severe cases, it can lead to suicidal behavior. Chronic, unpredictable, and mild stress (CUMS) modeling methods are widely used in depression research. The pathophysiological changes caused by this method are similar to human depression.

　　This article reviews CUMS modeling methods, model evaluation, and pathophysiological changes, and considers the above aspects.