动物造模,宫内感染动物模型 z-bio 2021-06-17 523

　　Intrauterine infections can invade the uterine cavity of pregnancy through various pathogens, and have adverse effects on mothers and babies, such as abnormal pregnancy, neonatal diseases, etc., but the cause is unknown, so the treatment effect is poor, and the prognosis is also poor. Therefore, the establishment of a stable and reliable animal model of intrauterine infection is helpful for more detailed research on its pathogenesis, drug action mechanism and prevention, and is of great significance for reducing adverse maternal and infant outcomes and improving prognosis.

　　At present, the established animal models of intrauterine infection at home and abroad mainly include E. coli or lipopolysaccharide-induced intrauterine infection models, Ureaplasma intrauterine infection models, Candida intrauterine infection models, and cytomegalovirus. Model etc. ..

　　This article mainly discusses the choice of experimental animals, the experimental design of various modeling methods, and their advantages and disadvantages.