动物造模,颅骨缺损动物模型 z-bio 2022-06-29 1041

　　Objective: To explore an ideal method to establish a rat skull defect model, and to improve the success rate of animal models of bone defect.

　　Method: Select 40 adult male SD rats and randomly divide them into a control group and an experimental group. The control group used conventional skull defect model surgery and only used a hollow ring drill perpendicular to the surface of the skull. The experimental group drilling a full-thickness skull defect adopted an improved surgical method, using hollow drills and solid drills to reorient the drill force at all stages of the skull drilling process. Compare the number of surgical drill holes of the two models and the presence of complications such as periosteum, dura mater, brain tissue damage and bleeding during the operation, and the alumina bioceramic material implanted within 8 weeks of the two models to observe whether they are displaced , Compare the degree of looseness and osseointegration, as well as the success rate of the two groups.

　　Results: Compared with the control group, the surgical excavation time in the experimental group was significantly shortened (Pu003c0.01), and intraoperative complications such as periosteum, dura mater, brain tissue damage, hemorrhage, etc. were significantly reduced (Pu003c0.01). Alumina bioceramic material There was no displacement or loosening after the operation (Pu003c0.05), the material was well integrated with the skull, and the success rate of model building was significantly improved (Pu003c0.05). 05).

　　Conclusion: An improved method for establishing a rat skull defect model has the advantages of shorter surgical drilling time and fewer complications. This greatly improves the success rate of model establishment and can effectively evaluate the bone repair performance of orthopedic implant materials in vivo.