动物造模,宫内感染动物模型 z-bio 2021-10-12 612

　　Intrauterine infection can be invaded by various pathogens in the uterine cavity of pregnancy, causing abnormal pregnancy, neonatal diseases and other harmful consequences for the mother and baby, but the cause is unknown, so it is invalid and the prognosis is poor. Therefore, the establishment of a stable and reliable animal model of intrauterine infection is helpful for more detailed research on its pathogenesis, drug action mechanism and prevention, and is of great significance for reducing adverse maternal and infant outcomes and improving prognosis.

　　The currently established animal models of intrauterine infection mainly include E. coli or lipopolysaccharide-induced intrauterine infection models, Ureaplasma intrauterine infection models, Candida intrauterine infection models, and animal models including cytomegalovirus intrauterine infection.

　　This article mainly discusses the choice of experimental animals, the experimental design of various modeling methods, and their advantages and disadvantages.