【Animal Modeling】-How to build an animal model of vein bypass graft disease?

  Cardiovascular disease is the largest disease burden in the world. Ischemic heart disease seriously threatens people's physical and mental health, and the morbidity and mortality rates are still rising. Coronary artery bypass grafting is one of the treatment methods for ischemic heart disease. It is effective in rebuilding the blood supply of the heart, but it faces the problem of insufficient long-term patency of grafted veins. Therefore, stable animal models can provide tools for the research and resolution of vein bypass graft diseases.

  This article summarizes the establishment and application of venous bypass disease animal models, and provides new ideas for the establishment of disease animal models.