动物造模,非酒精性脂肪肝炎动物模型 z-bio 2021-06-18 371

　　As the global prevalence of metabolic syndrome continues to rise, the prevalence of non-alcoholic fatty liver (NAFLD) is also rising. NAFLD, including simple fatty liver and non-alcoholic steatohepatitis, has become the most common chronic liver disease . (NASH), advanced fibrosis, cirrhosis and hepatocellular carcinoma.

　　And NASH is an important stage from simple fatty liver to liver fibrosis, cirrhosis, and liver cancer, so the prevention and treatment of NASH is the focus of research. Animal models are an important part of studying disease pathogenesis, developing therapeutic drugs, and formulating prevention and treatment strategies. The animal models currently developed mainly simulate the pathological morphology and clinical characteristics of human NASH, including prey, drug-induced animals, and transgenic animal models, each with its own advantages and disadvantages.

　　This article summarizes the latest research and application of NASH animal models for the reference of NASH researchers.