动物造模,母婴分离模型 z-bio 2021-06-21 257

　　Purpose: Maternal separation (MS) has always been a classic animal model for studying the neurobiological mechanism of the adverse effects of early stress on individuals' physiology and psychology, and is an important early social deprivation. This article reviews the biological mechanisms related to the general behavioral paradigm of MS models in rats and mice, and reveals the various effects of the duration and frequency of mother-infant separation on experimental results.

　　Method: From Wanfang, HowNet, Pubmed and other platforms. The MS model is used to explore the relevant literature on the long-term cognitive and psychological effects of adolescent stress on rats and mice to evaluate behavioral methods and results. Article and its underlying mechanism.

　　Result: The establishment of the rodent MS model provides a new way for people to explore the long-term psychological and physical disorders related to childhood negative events, and shows a wide range of applicability.

　　Conclusion At present, various studies have made some progress on this basis, and multi-dimensional studies have been conducted on the cognition, psychological changes and pathogenesis of animal models. However, the cognitive and behavioral changes caused by different separation frequencies and durations are still uncertain, and further studies on their effects on gene expression of offspring and parents are needed.