动物造模,阿尔茨海默病 z-bio 2021-10-22 441

　　Objective: To explore the characteristics of early sensory working memory deficits in Alzheimer's disease transgenic mice?

　　"Method: 5-week-old male 5XFAD transgenic mice and 9 wild-type mice, and 9-week-old male 5XFAD transgenic mice and wild-type mice were used. The sensory width of each test of the eight kinds of mice, the number of sensory recognition errors, and the accuracy of the sensory width test?

　　Result: Compared with wild-type mice of the same age, is the sensory width of 9-week-old transgenic mice significantly reduced (P0.05)?

　　Conclusion: 9-week-old 5XFAD transgenic mice show obvious sensory working memory impairment, suggesting that sensory working memory impairment may be a sensitive indicator of early cognitive impairment in AD mouse models?