动物造模,实验动物 z-bio 2021-06-23 417

　　Purpose: To provide a reference for the selection of experimental animals in liver research by comparing the liver similarities of four commonly used experimental animal livers: mice, rats, guinea pigs, rabbits and humans.

　　Method: The livers of normal mice, rats, guinea pigs and rabbits were compared with human livers in terms of morphological characteristics, lobes, organ coefficients, and hepatocyte nucleus-to-mass ratio.

　　Result: The shape of rabbit liver is similar. The closest is the irregular rust and the wedge, and the ratio of the two nuclei to the plasma is also close to 0.158 and 0.149, respectively. Both guinea pig and human liver have 5 leaves, and the organ coefficient is closest to 3.096 and 2.35.

　　Conclusion: Rabbits and guinea pigs are closer to humans in histological characteristics, and may be more suitable for liver-related research?