动物造模,大鼠自发性肝胆管增生 z-bio 2021-06-23 323

　　Purpose: How to accumulate valuable rat hepatobiliary hyperplasia research data for the research and safety evaluation of new drugs?

　　Method: Divide the rats into 3 groups, the first group consists of 30 male and female animals (imported SD rats). One group of 60 males and 60 (domestic SD rats); the third group of 60 males and females (domestic Wistar rats)? At the end of the experiment, all experimental animals were euthanized, systematically dissected, and livers were prepared for tissue diseases. .. Physical examination and immunohistochemical research?

　　Results: There were varying degrees of bile duct hyperplasia in the hepatic duct area of rats in each group. The total incidence was 32.33. The incidence of domestic SD rats was significantly higher than that of imported SD rats. Rats (26.67?1.67?; domestic Wistar rats have a significantly higher incidence than domestic SD rats (53.33?26.67?; male animals have a significantly higher incidence than female animals (20?12.33). High pathological observations show how many bile ducts are Types of hyperplasia and fibrosis changes. The incidence of grade I and II lesions in rats is 84.5? The incidence of grade III lesions is only 15.5? Does the proliferation of oval cells indicate bile duct hyperplasia and differentiation into bile duct epithelium?

　　Conclusion: Are there differences in the incidence of hepatobiliary hyperplasia in rats of different species and genders? Can the results of this study be used to provide references for age-related animal and human hyperplasia for hepatobiliary tract research?