动物造模 z-bio 2021-07-01 301

　　Objective: To use infrared thermal imaging technology to evaluate the rise and fall of "Yang Qi" in mice with glucocorticoid drug-induced syndrome.

　　Method: 120 ICR mice were divided into 3 experiments, which were carried out in sequence. Each experiment was divided into a conventional control group and four different doses of glucocorticoids (hydrocortisone, prednisolone, dexamethasone). On the 14th day of the administration, the infrared thermal image of each group of mice was taken to try to analyze the temperature of the head, flanks and spine of the mice.

　　Result: After the administration of hydrocortisone and dexamethasone, the maximum head temperature, average trunk temperature and minimum tail temperature of mice all decreased to varying degrees. After prednisolone was administered, the maximum head temperature of mice in the ultra-low dose group was significantly reduced.

　　Conclusion: Infrared thermal imaging technology can evaluate the degree of rise and fall of the “yang” of experimental mice. Hydrocortisone and dexamethasone can induce the same external cold symptoms as positive deficiency in mice with drug-induced deficiency.