动物造模,免疫细胞 z-bio 2021-07-01 276

　　Purpose: How to compare and observe the differences in peripheral blood and immune system related indicators between old C57BL/6J mice and young C57BL/6J mice?

　　Method: Collect 19-month-old and 2-month-old C57BL/6J mice to detect peripheral blood cell counts? Immune organ index and peripheral blood immune cell typing?

　　Result: Compared with young mice, the number of peripheral blood red blood cells and platelets in old mice increased, the ratio of neutrophils increased, and the ratio of lymphocytes decreased (Pu003c0.001). CD4+ cells are significantly reduced (Pu003c0.001), and the thymus index is significantly reduced (Pu003c0.001)?

　　Conclusion: The differentiation of blood cells in old mice is deviated, and the number of helper T cells is reduced, similar to that of young mice. Obvious difference, similar to the changes in blood substitute immune aging? Does this study provide basic data for research on immune aging-related issues?