动物造模 z-bio 2021-07-01 467

　　According to a study published this week in the Journal of Applied and Environmental Microbiology, genetics has a greater impact on the microbiome than the maternal delivery environment, at least in mice. It is well known that the transfer of microbial flora to the vaginal delivery of newborns does not produce persistent microbial traces in the offspring.

　　"Compared to the environment, the powerful role of genetics is amazing," said Yechezkel Kashi, director of the Institute of Applied Genomics and Microbiology at the Technion-Israel Institute of Technology. "This is disappointing because it shows that the benefits of probiotics can only last for one year."

　　In this study, the researchers discovered the microbiota of two different inbred strains of mice, namely mice (C57BL/6J) and white mice. (BALB/c). Then the researchers passed a black and white mouse. In one group of crosses, the mother is black, while in the other group, the mother is white. In both cases, the offspring have the same shade of gray and have similar inheritance, regardless of which parent is black and which is white.

　　Mammal mating transfers microorganisms from the canal where the mother was born to the offspring. Therefore, at birth, black and white mothers pass on different microbial flora to their offspring. The influence of the maternal environment on the offspring's microbial flora is negligible. The microbial flora of the offspring, whether black or white, are similar to each other, indicating that the mother did not sow the seeds at birth.

　　In the third experiment, we tested various environmental impacts-food sources-microbiota. In this experiment, we put a black rat and a black rat together. Dr. Hila Korach-Rechtman, co-author of the Israel Institute of Applied Genomics and Microbiology, Haifa Institute of Technology, explained: “Mouses are feces.” “They eat feces and cages. In this experiment, the white rats were exposed to the black rat microorganisms, and vice versa. The same is true.

　　These are some of the microbiome. However, as long as the rats occupy the same cage, this difference still exists. Dr. Korach-Rechtman said that when different mouse strains are separated, their microbiomes will return to their original composition. "Obviously, we cannot say that the same model applies to humans," said Dr. Kashgar. However, other evidence supports this hypothesis. Studies have shown that in mice and humans, specific sites or genes are related to specific microbial species.

　　Genetic variation is "other inheritance", such as "differences in mucosal and intestinal structure...metabolic differences, such as bile acid secretion...potential olfactory receptor activity...and antimicrobial peptides and immune mechanisms." The decisive system affects the intestinal flora . "The researcher wrote.

　　In order to analyze the effects of maternal strains and feces, the researchers collected the feces of various inbred mouse strains, analyzed the microbial community using DNA extraction and sequencing, and analyzed the results. Through bioinformatics analysis. The conclusion of the two experiments: genetics has an important influence on the microflora.