猴B病毒 z-bio 2021-07-02 462

　　Monkey B virus is the most dangerous zoonotic virus that infects non-human primates, and can cause serious infectious diseases that coexist with humans and monkeys. Monkey B virus is also called simian herpes virus type 1. It belongs to the alpha herpesvirus subfamily of the herpesvirus family. Both human herpes simplex virus type 1 and human herpes simplex virus type 2 are members of the herpes simplex virus genus.

　　When the monkey B virus infects its natural host, the rhesus monkey, it is benign and does not cause obvious clinical symptoms. Its clinical manifestations are similar to human HSV-1 infection. The characteristic symptoms are small herpes on the back of the tongue, oral mucosa, skin, and other oral areas. The herpes then ruptures, forming ulcers, and fibrous exudates appear on the surface. .. Scab formation, usually heals within 7-14 days without leaving scars. Virus B can be latent in the ganglia, tissues and organs near the upper respiratory tract or the genitourinary system for a long time, and is detoxified intermittently through saliva, urine and secretions of the genitourinary system. It is possible. The mechanism is similar to HSV. The first virus replication occurs at the mucosal infection site, and then it is absorbed by sensory and motor nerve endings, transported to sensory neurons through axons, and lurking in sensory ganglia. During the incubation period, the virus stops replicating. B virus is activated from the latent state, spreads to mucosal epithelial cells through axons, and replicates. With repeated infections, the virus can be released intermittently, causing social pressure, transportation, immunosuppression, and an increase in all new breeding environments. Possibility of reactivation and release. There is only one case of human-to-human transmission of B virus, mainly through mating, bites or scratches, and toxic saliva. The typical clinical course of human infection with B virus appears 1-3 days after exposure. Symptoms are similar to the common cold, with blisters, fever, muscle aches, discomfort, and headaches in the exposed area. Other symptoms include lymphangitis. Nausea, vomiting, abdominal pain. When the virus spreads, the central or peripheral nervous system may also experience symptoms of infection, such as ataxia, hyperthermia, paralysis, and allergies. The death rate of untreated infected persons is as high as 80? The survivors also suffered from sequelae of the nervous system, and their neurological function further deteriorated.

　　Monkey B virus and HSV are two homologous viruses. Humans and rhesus monkeys come from apes and are a common ancestor. With the development of biology, these two viruses have co-evolved with their respective hosts. Humans and rhesus monkeys are in different ecological niches, and there is a natural environmental barrier between them. The influence of certain natural and human factors can transcend the ecological niche and pose a risk of exposure to monkey B virus. Monkey B virus can only cause human infection by crossing environmental barriers. The clinical symptoms and results after infection depend on the toxicity of the virus and the interaction between the host and the virus.